ABSTRACT
Helminth infections are the most common health problems in India, in developing countries they pose a large treat to public. These infections can affect most population in endemic areas with major economic and social consequences. The plant Bauhinia Racemosa Linn. is a species of flowering plant belongs to Fabaceae family. The different parts of plant being traditionally used in catarrh, infection of children, boil, glandular and swelling. The present study was undertaken to evaluate anthelmintic activity of different extracts of whole plant of Bauhinia Racemosa Linn. The different successive extracts namely petroleum ether, ethanol and aqueous using an adult Indian earthworms, Pheretima posthuma as a test worm. Three concentrations (50, 75 and 100 mg/ml) of each extracts were studied in the bioassay which involved the determination of time of paralysis and time of death of the worm. Albenzadole in same concentration as that of extract was included as standard reference and normal saline water as control. The results of present study indicate that the crude ethanolic extract significantly demonstrated paralysis and also caused death of worm in dose dependent manner, while aqueous and petroleum extracts show weak anthelmintic effect. Further studies are in process to isolate the active principles responsible for the activity.
ABSTRACT
Mucoadhesion had been a topic of interest in the design of drug delivery system to prolong the residence time of the dosage form with the under lying absorption surface to improve and enhance the bioavailability of drugs. Mucoadhesion occurs between two surfaces, one of which is a mucous membrane and another is drug delivery system. Pharmaceutical aspects of mucoadhesion had been the subject of great interest during recent years because mucoadhesion could be a solution for bioavailability problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption site within the gastro-intestinal tract. It had been a great challenge to the pharmaceutical sciences in order to enhance localised drug delivery or to deliver ‘difficult’ molecules (proteins and oligonucleotides) into the systemic circulation. Mucoadhesive systems remain in close contact with the absorption tissue, the mucous membrane releasing the drug at the action site leading to increase in bioavailability (both local and systemic effects). Extending the residence time of a dosage form at a particular site and controlling the release of drug from the dosage form are useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The main objective of this study was to selectively collect the data which were extended the gastrointestinal residence time of the dosage form and controlled the release of mucoadhesives.